AUC (Area Under Curve)
Also known as: area under the curve · total exposure
The integrated total exposure of the body to a peptide over time, calculated as the area under the concentration-time curve.
AUC is the gold-standard metric for cumulative drug exposure. Two protocols with identical weekly AUC can have radically different Cmax and Cmin profiles — and thus radically different side-effect and efficacy profiles. When comparing dose schedules, AUC-matching rather than milligram-matching is the correct apples-to-apples comparison.
In practitioner audits, most 'unexpected' results from dose splitting or frequency changes can be explained by shifts in the Cmax/Cmin ratio at constant AUC. DoseCraft's protocol engine calculates AUC across stacked compounds to flag overlap exposure that static calculators miss.
A 2mg weekly Semaglutide injection has the same AUC as 1mg twice-weekly, but the twice-weekly schedule shows ~40% lower Cmax — which is why some researchers use twice-weekly splitting to manage nausea during titration.
Related Terms
Cmax
The maximum plasma concentration reached after a single dose of a peptide.
Cmin
The lowest plasma concentration of a peptide during a dosing interval, typically measured immediately before the next dose.
Half-Life
The time required for the concentration of a peptide in the body to fall to half of its peak value.
Bioavailability
The fraction of an administered peptide dose that reaches systemic circulation in an active, unmetabolized form.
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