GHRH Analog
Also known as: GHRH mimetic · growth hormone releasing hormone analog
A synthetic peptide that mimics endogenous growth hormone releasing hormone at the GHRH receptor on pituitary somatotrophs.
GHRH analogs include Sermorelin, Tesamorelin, and CJC-1295. They trigger GH release through the GHRH receptor, which is a different pathway than growth hormone secretagogues that use the ghrelin receptor. This is why stacking a GHRH analog with a GHS produces a larger combined GH pulse than either class alone — the two pathways converge on somatotrophs from different receptor angles and sum their effects.
CJC-1295 with DAC (drug affinity complex) extends the half-life from minutes to days by binding serum albumin, which is the same engineering principle used in modern GLP-1 analogs.
Related Terms
Growth Hormone Secretagogue
A compound that triggers endogenous growth hormone release from the pituitary, typically by activating the ghrelin/GHS-R1a receptor.
Stack
A combination of two or more peptides used concurrently to produce additive or synergistic effects on a research target.
Half-Life
The time required for the concentration of a peptide in the body to fall to half of its peak value.
Longevity Peptide
A class of peptides researched for effects on cellular aging markers, mitochondrial function, telomere maintenance, and healthspan extension.
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