Lyophilization
Also known as: freeze-drying · lyo
The process of freeze-drying a peptide to produce a stable, water-free solid powder for long-term storage.
Lyophilized peptides are shipped as a white or off-white powder inside sealed glass vials. The process removes water via sublimation at low temperature, which prevents the heat-induced degradation that spray-drying would cause. Properly lyophilized peptides are stable at room temperature for weeks and in refrigeration for months to years depending on compound.
A lyophilized vial that arrives with visible liquid, discoloration, or a 'puck' that dissolves unevenly has suffered process or shipping failure. The researcher's first visual inspection of the vial is a free quality check — practitioners routinely photograph vials on arrival as part of batch documentation.
Related Terms
Cold Chain
The unbroken maintenance of refrigerated temperatures during peptide storage, shipping, and handling.
Reconstitution
The process of dissolving a lyophilized peptide powder in bacteriostatic water or saline to produce an injectable solution.
Vial Shelf Life
The duration a peptide remains stable and potent in its current physical state (lyophilized or reconstituted).
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