Receptor Antagonist
Also known as: antagonist · receptor blocker
A molecule that binds to a receptor without activating it, preventing the endogenous ligand from triggering a response.
An antagonist occupies the receptor and blocks it. Competitive antagonists share the binding site with the natural ligand and can be overcome by higher ligand concentrations; non-competitive antagonists bind elsewhere and cannot be displaced by increasing ligand. Antagonists are rarer in peptide research contexts but appear in specialized use cases — for example, glucagon receptor antagonists under investigation for metabolic research.
Related Terms
Receptor Agonist
A molecule that binds to a receptor and triggers the same biological response as the endogenous ligand.
GLP-1 Receptor
A G-protein coupled receptor activated by glucagon-like peptide-1, expressed primarily in pancreatic beta cells, the central nervous system, and gastrointestinal tract.
GIP Receptor
A G-protein coupled receptor activated by glucose-dependent insulinotropic polypeptide, expressed in adipose tissue, pancreatic beta cells, and brain.
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