Tissue Residency
Also known as: tissue persistence · depot effect
The duration a peptide remains active within a specific tissue after plasma concentrations have fallen.
Plasma half-life and tissue half-life are not the same number. Some peptides — particularly repair-oriented compounds — clear from blood relatively quickly but persist at injured tissue sites where they accumulate due to local receptor binding and reduced clearance. This depot effect is why certain healing protocols show continuing benefit beyond the plasma clearance window.
Tissue residency is difficult to measure directly in research contexts and is often inferred from pharmacodynamic effects outlasting pharmacokinetic expectations. It's one of the reasons practitioner-sourced dosing guidance sometimes diverges from textbook PK — the textbook reports plasma, the practitioner sees tissue.
Related Terms
Volume of Distribution
A theoretical volume describing how extensively a peptide distributes from plasma into tissues.
Half-Life
The time required for the concentration of a peptide in the body to fall to half of its peak value.
Clearance Rate
The volume of plasma cleared of a peptide per unit time, typically by renal filtration, hepatic metabolism, or proteolytic degradation.
Look up any peptide term inside DoseCraft Pro
The glossary is just the start. Inside DoseCraft you get 90+ compound deep-dives, a PK-aware protocol engine, interaction checker, and vendor trust scores — every term surfaced in protocol-design context, not a separate page.
Start Free Trial