Semax & Selank: Russian Neuropeptides

Semax is a synthetic heptapeptide derived from ACTH (adrenocorticotropic hormone), specifically the 4-10 fragment, with an added Pro-Gly-Pro C-terminal tripeptide for stability. Developed in Russia in the 1980s, Semax has been approved as a prescription medication in Russia and Ukraine for stroke recovery, cognitive enhancement, and treatment of peptic ulcers. It works by increasing BDNF expression, modulating serotonin and dopamine metabolism, and enhancing enkephalin (endogenous opioid) levels without binding to opioid receptors directly.

Semax is administered intranasally at doses of 200-600mcg per day, typically split into 2-3 administrations. The intranasal route provides direct access to the CNS through the olfactory and trigeminal nerve pathways, bypassing the blood-brain barrier. Effects are often noticeable within 15-30 minutes and include improved focus, enhanced verbal fluency, reduced anxiety, and clearer thinking. The N-Acetyl-Semax-Amidate (NASA) variant is a more potent form with enhanced stability and increased BDNF stimulation, typically dosed at 100-300mcg intranasally.

Selank is a synthetic heptapeptide analog of the naturally occurring immunomodulatory peptide tuftsin. Also developed in Russia, Selank is primarily an anxiolytic (anti-anxiety) peptide that also enhances cognitive function. It modulates the GABAergic system (similar to benzodiazepines but without sedation or dependence), increases serotonin metabolism, and has immunomodulatory effects. Selank is administered intranasally at 250-500mcg per day. Many practitioners combine Semax (for focus and cognitive enhancement) with Selank (for anxiety reduction and emotional stability), creating a balanced stack that improves cognitive performance while reducing the stress response that can impair it.