Mapping Peptides to Root Causes

With the Three Root Causes framework as your guide, peptide selection becomes systematic rather than random. For inflammation-dominant profiles, the first-line peptides include BPC-157 for systemic repair and gut healing, KPV for direct NF-kB inhibition, Thymosin Alpha-1 for immune modulation, and GHK-Cu for tissue remodeling and anti-inflammatory gene expression. These can be combined based on severity: mild inflammation may respond to BPC-157 alone, while severe systemic inflammation may warrant a multi-peptide anti-inflammatory protocol.

For insulin resistance-dominant profiles, GLP-1 receptor agonists are the most impactful intervention. Semaglutide and tirzepatide have the strongest clinical evidence for improving insulin sensitivity and reducing body fat. MOTS-c provides a complementary mechanism through AMPK activation. AOD-9604 targets lipolysis specifically. For cognitive symptoms related to metabolic dysfunction, Dihexa and Semax can support neuroplasticity while metabolic restoration proceeds. The key principle is to match the potency of intervention to the severity of dysfunction.

For ATP shortage-dominant profiles, the priority is restoring mitochondrial function. Methylene Blue provides immediate ETC support. SS-31 stabilizes the mitochondrial membrane architecture. MOTS-c optimizes mitochondrial gene expression. NAD+ precursors (NMN, NR) restore the cofactors needed for oxidative phosphorylation. Epitalon, through its effects on telomerase activation and circadian rhythm restoration, supports the broader cellular maintenance systems that keep mitochondria healthy. In practice, most individuals present with all three root causes to varying degrees, which is why the Trilogy for Life serves as a foundation upon which targeted interventions are layered.