Path
NAD Optimization
NAD+ — nicotinamide adenine dinucleotide — is not optional. The practitioner corpus describes it as the substrate without which the electron transport chain refuses to catalyze.
For: See chapter one for the full framing.
◆ 10 quizzes◆ 10 slide decks
Learning objectives · Bloom-aligned · 12
- understandExplain how NAD+ collapse reflects mitochondrial bankruptcy rather than simple substrate deficiency, including the role of CD38, PARP, and SIRT consumption
- analyzeAnalyze why repairing mitochondrial membrane integrity must precede NAD+ substrate loading to avoid wasted supplementation spend
- applyApply Phase 1 NAD+ loading and membrane repair protocols across Weeks 1-4 with correct reconstitution math, injection schedule, and clearance-of-static markers
- applyApply Phase 2 mitochondrial biogenesis stack across Weeks 5-10, layering MOTS-c on Mon/Thu, 5-Amino-1MQ daily, and nightly GH pulse with correct timing
- evaluateEvaluate the supporting axis dependencies — circadian rhythm, cortisol slope, and growth hormone timing — that gate NAD+ protocol response
- analyzeAnalyze cellular energy lab panels — distinguishing lagging markers (HbA1c, body comp) from leading markers (lactate, RHR, HRV, fasting insulin) and their pull cadence
- evaluateEvaluate Week 1-4 subjective response signals (energy floor, sleep architecture, day-10 inflection) against expected Phase 1 reset trajectory
- analyzeAnalyze the metabolic flexibility shift produced by Phase 2 — fuel substrate switching, fasted-state performance, and biogenesis biomarkers
- evaluateEvaluate practitioner response category — clear responder, partial responder, or non-responder — using lab + subjective data to select the next-protocol branch
- createCreate an individualized maintenance protocol using low-dose NAD+ pulses, annual rebuild cycles, and continuous supporting-axis monitoring
- applyApply correct injection-site rotation, dose math, and timing windows for MOTS-c, 5-Amino-1MQ, and GH-axis peptides across both protocol phases
- createCreate a personalized adjustment plan that modifies dose, frequency, or stack composition based on Week 10 lab deltas and response classification
Chapters · 10
- 01What's actually happening when NAD collapses
- 02Chapter 2 — The upstream lever: mitochondrial integrity before substrate
- 03Chapter 3 — Phase 1 reset: NAD+ loading and mitochondrial repair (Weeks 1-4)
- 04Phase 2 rebuild — mitochondrial biogenesis and metabolic flexibility (Weeks 5-10)
- 05Chapter 5 — Supporting axis: circadian, cortisol, and growth hormone timing
- 06Labs that matter — measuring cellular energy, not guessing
- 07Weeks 1–4 execution — the daily reset rhythm
- 08Weeks 5-10 execution layering the rebuild stack
- 09Adjusting based on labs clear partial or no response
- 10Maintenance — the long game of cellular energy
Research use only · Not medical advice