Path
TRT Men
Testosterone production runs on a closed feedback loop between three endocrine glands: the hypothalamus, the anterior pituitary, and the testes (specifically, the Leydig cells…
For: See chapter one for the full framing.
◆ 10 quizzes◆ 10 slide decks
Learning objectives · Bloom-aligned · 11
- analyzeAnalyze the HPG axis cascade — hypothalamic GnRH pulsatility, pituitary LH/FSH output, and Leydig cell response — to explain why exogenous testosterone suppresses endogenous production
- evaluateEvaluate the tradeoffs of axis-restart protocols versus lifelong exogenous testosterone replacement for fertility, longevity, and protocol durability
- applyApply Kisspeptin and Gonadorelin dosing, timing, and titration during the Week 1-4 Phase 1 reset to restart pituitary-gonadal signaling
- applyApply the CJC-1295 + Ipamorelin nighttime GH stack across Weeks 5-10 to restore recovery, sleep architecture, and lean-mass signaling on top of the Phase 1 base
- analyzeAnalyze the interaction between testosterone optimization and the supporting endocrine axes — thyroid (T3), cortisol, and estradiol balance — that determine whether T optimization actually translates to symptom relief
- analyzeInterpret the lab panel — total T, free T, SHBG, LH, FSH, sensitive estradiol, hematocrit, and IGF-1 — distinguishing leading from lagging markers and selecting appropriate draw timing windows
- applyExecute injection mechanics, site rotation, and sleep-aligned timing on the Weeks 1-4 daily and weekly schedule to meet the compliance threshold the protocol depends on
- evaluateEvaluate clear-responder, partial-responder, and non-responder lab trajectories at Week 10 to select the appropriate next protocol branch
- createCreate a long-game maintenance protocol with low-dose pulsed dosing, quarterly lab cadence, and lifestyle layering that sustains optimization while preserving fertility
- understandUnderstand why hypothalamic and pituitary restoration is the upstream lever that beats downstream hormone replacement for most men
- analyzeAnalyze how the Phase 1 axis-restart and Phase 2 GH-axis rebuild stack without inducing shutdown across the full 10-week build
Chapters · 10
- 01What's actually happening when testosterone drops
- 02Chapter 2 — The upstream lever: restart the signal, don't replace the hormone
- 03Phase 1 reset week 1-4 restart the pituitary gonadal signal
- 04Phase 2 rebuild (Week 5-10) — layer the GH axis for body composition
- 05Supporting axes thyroid cortisol and the estradiol balance
- 06Labs that matter what to pull when and what's actually
- 07Weeks 1-4 schedule — daily and weekly rhythm
- 08Weeks 5–10 schedule — layering CJC-1295 + Ipamorelin
- 09Adjusting based on labs — clear, partial, no response
- 10Maintenance — sustained optimization, fertility preserved
Research use only · Not medical advice