Loading...
How MOTS-c, 5-Amino-1MQ, SS-31, and BPC-157 address inflammation, insulin resistance, and ATP shortage
Menopause doesn't just reduce estrogen — it disrupts the entire metabolic system through three interconnected root causes. Understanding these is the key to building an effective protocol.
The Three Root Causes
Most interventions target only ONE root cause. This protocol addresses all three simultaneously — which is why it produces compound (no pun intended) results.
Dose
5mg, three times per week
Frequency
Mon / Wed / Fri
Route
Subcutaneous injection
Mechanism: Mitochondrial-derived peptide that activates AMPK signaling — the same pathway triggered by exercise. Improves metabolic flexibility, glucose uptake, and fat oxidation.
Dose
50mg daily
Frequency
Once daily, morning
Route
Oral capsule
Mechanism: NNMT enzyme inhibitor. Blocks the enzyme that depletes NAD+ and promotes visceral fat storage. Supports metabolic efficiency and cellular energy recycling.
Dose
40mg daily
Frequency
Once daily
Route
Subcutaneous injection
Mechanism: Targets cardiolipin in the inner mitochondrial membrane, stabilizing the electron transport chain and restoring ATP production. One of the few compounds with direct mitochondrial access.
Dose
500mcg daily
Frequency
Once daily, morning
Route
Subcutaneous injection only (oral is ineffective)
Mechanism: Anti-inflammatory peptide that modulates TNF-alpha, IL-6, and nitric oxide pathways. Addresses the chronic inflammatory cascade triggered by estrogen decline.
| Weeks 1-2 | Start BPC-157 and 5-Amino-1MQ only. Half-dose MOTS-c (2.5mg 2x/week) to assess tolerance. |
| Weeks 3-8 | Full protocol: all four compounds at target doses. Monitor energy, sleep quality, body composition. |
| Weeks 9-12 | Continue BPC-157 and 5-Amino-1MQ. Cycle MOTS-c to 2x/week. Assess SS-31 response. |
| Bloodwork | Baseline + Week 8: fasting insulin, fasting glucose, CRP, IGF-1, lipid panel, CBC |
| Monthly cost | $200-350 depending on vendor and dosing |
Log doses, monitor interactions, and optimize your stack with AI tools.
Open DoseCraftPharma-grade, third-party tested. Our preferred vendor for the DoseCraft community.
Shop Peptide PartnersEach compound targets a different root cause, but they also create synergistic effects. MOTS-c and SS-31 both improve mitochondrial function through different mechanisms (AMPK activation vs. membrane stabilization). 5-Amino-1MQ supports the NAD+ pool that both mitochondrial peptides depend on. And BPC-157 reduces the inflammatory load that accelerates all three root causes. The result is a protocol where each compound amplifies the others.
This article is for educational purposes only. This is not a prescription. Consult a licensed healthcare professional before starting any peptide protocol, especially during menopause when hormonal changes affect drug metabolism.
Track your protocol with precision tools. Source pharma-grade compounds from a trusted vendor.
Build this protocol in 60 seconds. AI-powered dose logging, half-life tracking, and interaction checks.
Open Protocol BuilderPharma-grade, third-party tested peptides from our preferred vendor. Trusted by the community.
Shop Peptide PartnersLeading clinical practitioners identify three root causes underlying virtually all chronic disease: systemic inflammation, insulin resistance, and ATP (energy) failure. Understanding this framework transforms how you approach health optimization with peptides.
Read researchMetabolic flexibility is your body's ability to switch between glucose and fat as fuel. When it breaks down, you get energy crashes, stubborn fat, and insulin resistance. Here's the peptide approach to restoring it.
Read researchMOTS-C is a mitochondrial-derived peptide that activates AMPK, enhances complex I function, drives mitochondrial biogenesis, and improves insulin sensitivity. Leading practitioners consider it one of the most important peptides for metabolic optimization and longevity.
Read researchNot medical advice — educational only. DoseCraft is an information and personal tracking platform. We do not provide medical advice, diagnosis, or treatment. Always consult a licensed healthcare professional before starting any protocol. Affiliate links may be present — we only recommend vendors we trust.