Off-Cycle
Also known as: washout period · rest phase
The pause phase of a peptide cycle during which no compound is administered, allowing receptor recovery and isolated outcome measurement.
Off-cycle serves two purposes: receptor resensitization (where applicable) and outcome persistence assessment. If a result disappears within the off-cycle window, it was compound-dependent; if it persists, the cycle produced lasting change. Off-cycle length should exceed 4–5 half-lives of the longest compound in the stack — shorter off-periods measure plasma clearance rather than actual biological persistence.
Off-cycle is also when bloodwork normalizes for baseline comparison on the next cycle. Mid-off-cycle bloodwork is a more informative baseline than immediate post-cycle bloodwork, which still reflects compound carryover.
Related Terms
On-Cycle
The active phase of a peptide cycle during which the compound is being administered.
Cycle
A defined period of peptide administration followed by a planned pause, structured to manage receptor sensitivity and measure effects.
Receptor Desensitization
The reduction in receptor responsiveness over time due to sustained or high-dose agonist exposure.
Half-Life
The time required for the concentration of a peptide in the body to fall to half of its peak value.
Look up any peptide term inside DoseCraft Pro
The glossary is just the start. Inside DoseCraft you get 90+ compound deep-dives, a PK-aware protocol engine, interaction checker, and vendor trust scores — every term surfaced in protocol-design context, not a separate page.
Start Free Trial