Telomerase Activation
Also known as: TA · telomere lengthening
The upregulation of telomerase enzyme activity, which extends or maintains telomere length at the ends of chromosomes.
Telomeres cap chromosome ends and shorten with each cell division; telomerase rebuilds them. Most somatic cells express low telomerase, which limits replicative lifespan; stem cells and germline cells express high telomerase. Compounds researched for telomerase activation — notably Epitalon — are of interest in longevity contexts because telomere attrition correlates with cellular senescence markers across tissues.
The tradeoff is well-documented: robust telomerase activation is a hallmark of many cancer cells. This is why telomerase-targeting compounds remain research-only and why any protocol incorporating them warrants comprehensive baseline and ongoing bloodwork.
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