Semaglutide
GLP-1Single-receptor GLP-1 agonist. The most-prescribed, best-evidenced.
- Receptor
- GLP-1 only
- Half-life
- ~7 days
- Cadence
- Weekly subcutaneous
- Typical loss
- ~15% body weight @ 68 weeks (STEP-1 trial)
Weekly dosing. Multi-week titration. Side-effect curves you can’t fake. Most habit trackers weren’t built for this. DoseCraft was.
Weekly dosing breaks habit-tracker math. Most apps assume daily cadence. GLP-1 protocols are weekly with multi-week titration steps. The compliance picture only works when the tracker thinks in weeks, not days.
Titration is the whole game. Dose-escalation steps can bring nausea and other side effects. Logging symptoms alongside your prescribed dose gives your clinician a clearer picture when you discuss whether to continue, pause, or adjust treatment. Don’t change your dose without clinical guidance.
Plasma concentration matters. With a 5–7 day half-life, drug levels change gradually. A half-life chart estimates that change; it cannot determine your therapeutic threshold. Follow your medication’s instructions and ask your clinician about missed doses.
Same family, different receptor profiles. Pick by goal, evidence depth, and tolerability.
Single-receptor GLP-1 agonist. The most-prescribed, best-evidenced.
Dual GLP-1 + GIP agonist. Stronger weight-loss data, comparable tolerability.
Triple GLP-1 + GIP + glucagon agonist. Phase III, not yet FDA-approved.
The features that actually move the needle when you’re titrating a GLP-1.
Record your prescribed dose and set weekly reminders. Many GLP-1 schedules increase doses in multi-week steps; your clinician guides each change.
Nausea, GI distress, fatigue, injection-site reactions — log severity 1–10 against the dose schedule. Spot which step is intolerable before it derails the cycle.
Track weight and body-fat % over time. Review your weight trend alongside your dose log to discuss changes with your clinician.
Explore estimated concentration over time and set weekly dose reminders. The chart is a model, not a measured drug level or a guide to changing your dose.
5 mg vial + 2 mL bac water → 250 mcg per 0.1 mL → 10 units on a U-100. Calculator runs the math, syringe visual confirms the draw line.
Coach explains research on common GLP-1 side effects and helps you prepare questions for your clinician. Dose changes need clinical guidance.
Semaglutide and Tirzepatide are weekly subcutaneous incretin agonists, but they target different receptors. Trials show differences in average weight loss; side effects, access, and cost also matter. Both require gradual dose escalation under clinical supervision. Coach helps you explore the research and prepare questions for your clinician.
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