HPLC (High-Performance Liquid Chromatography)
Also known as: HPLC · liquid chromatography
An analytical technique that separates, identifies, and quantifies compounds in a sample based on differential affinity with a chromatographic column.
HPLC is the industry-standard purity test for peptides. A typical COA reports HPLC purity as a percentage — a reputable vendor targets ≥98%. HPLC alone cannot confirm peptide identity; it can only confirm that a single dominant compound is present and report its purity relative to contaminants. This is why HPLC should always be paired with mass spectrometry on a complete COA.
'HPLC-only' vendors are a documented cost-cutting pattern. They're saying 'something ≥98% pure is in this vial' without confirming what that something actually is.
Related Terms
COA (Certificate of Analysis)
A third-party laboratory report documenting the purity, identity, and mass of a peptide batch.
Mass Spectrometry
An analytical technique that ionizes a compound and measures the mass-to-charge ratio of its fragments to confirm molecular identity.
Vendor Trust Score
A composite metric evaluating peptide vendor reliability based on COA verification, batch consistency, shipping quality, and community feedback.
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