Mass Spectrometry
Also known as: MS · mass spec
An analytical technique that ionizes a compound and measures the mass-to-charge ratio of its fragments to confirm molecular identity.
Mass spectrometry is the identity check — it answers the question 'is this molecule the peptide we think it is?' HPLC answers 'how pure is it?' A complete COA contains both: HPLC for purity quantification and MS for identity confirmation. The MS output should show a molecular mass matching the theoretical mass of the target peptide to within acceptable tolerance.
Substitution scams — where a vendor ships a cheaper peptide labeled as a more expensive one — are detectable only through mass spectrometry. HPLC-only COAs are structurally unable to catch this failure mode.
Related Terms
HPLC (High-Performance Liquid Chromatography)
An analytical technique that separates, identifies, and quantifies compounds in a sample based on differential affinity with a chromatographic column.
COA (Certificate of Analysis)
A third-party laboratory report documenting the purity, identity, and mass of a peptide batch.
Vendor Trust Score
A composite metric evaluating peptide vendor reliability based on COA verification, batch consistency, shipping quality, and community feedback.
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