The Three Root Causes
The foundational clinical framework for understanding why we age, get sick, and die. Three biological failures drive a “death spiral” — each feeds the others. Address all three or address none.
The Three Failures
Systemic Inflammation
The Silent Fire
Chronic, body-wide inflammatory cascade that accelerates aging and disease. Every cell bombarded by pro-inflammatory cytokines. The immune system attacks its own tissues, breaking down barriers and amplifying damage across every organ system.
Mechanism
NF-kB pathway activation, elevated TNF-alpha, IL-6, CRP. Gut permeability ('leaky gut') feeds systemic inflammation. Crosses the blood-brain barrier causing neuroinflammation.
Insulin Resistance
The Metabolic Lock
Cells can't properly uptake glucose. Metabolic dysfunction cascading into every organ system. The body produces more and more insulin to compensate, driving fat storage, inflammation, and eventually organ failure.
Mechanism
Downregulated GLUT4 receptors, hyperinsulinemia, impaired AMPK signaling. Fat accumulates in liver, pancreas, and muscle tissue. Drives visceral adiposity and accelerates aging.
ATP Shortage
The Energy Crisis
Mitochondria can't produce enough energy. 'Fatigue is a mismatch between energy demand and supply at the cellular level.' When ATP drops, every biological process degrades — repair, detox, cognition, immunity.
Mechanism
Dysfunctional electron transport chain, excessive ROS production, NAD+ depletion. Damaged mitochondria produce less ATP while generating more oxidative stress, creating a vicious cycle.
The Death Spiral
Each root cause amplifies the others. Inflammation drives insulin resistance. Insulin resistance starves mitochondria of resources. ATP shortage cripples repair mechanisms, fueling more inflammation. Without intervention, the spiral accelerates.
Systemic Inflammation
Insulin Resistance
ATP Shortage
Pro-inflammatory cytokines (TNF-alpha, IL-6) directly impair insulin receptor signaling and GLUT4 translocation.
Glucose can't enter cells efficiently. Mitochondria are starved of substrate. Excess glucose glycates proteins, damaging ETC complexes.
Low ATP disables cellular repair. Damaged mitochondria leak ROS. Oxidative stress triggers NF-kB, reigniting the inflammatory cascade.
Trilogy for Life
The signature daily stack — one compound targeting each root cause. The minimum effective intervention to break the death spiral. The framework treats it as the foundation everyone should be on.
The premise
If you could only take three things for the rest of your life: BPC-157, MOTS-c, and Methylene Blue. That's the Trilogy for Life.
Root Cause Coverage
- Inflammation
- BPC-157
- Insulin Resistance
- MOTS-c
- ATP Shortage
- Methylene Blue
Desert Island Peptides
The answer to “If you were stranded on a desert island and could only bring four compounds, which would you take?”
Built from experienced-practitioner protocols
Cross-checked against published research and labeled by evidence strength throughout DoseCraft.