Free Peptide Guides
Evidence-based resources built by leading practitioners and researchers. Enter your email to unlock any guide — instant download, no strings attached.
The Three Root Causes Framework
Understand the three foundational drivers behind most health decline: inflammation, insulin resistance, and ATP shortage. The framework that powers DoseCraft's protocol engine.
First Stack Decision Framework
A decision framework for building your first peptide stack. Covers the 6 questions every beginner must answer, how to evaluate your goals against the Three Root Causes, and what to discuss with your healthcare provider.
The Bloodwork Checklist
Every biomarker you should track before, during, and after peptide protocols. Includes optimal ranges, testing frequency, and what each marker tells you about your protocol's safety.
BPC-157 Research Summary
Research overview of BPC-157: mechanism, evidence classification, contraindications, and what to look for in a quality source. The peptide most cited for tendon, ligament, and gut healing.
TB-500 Research Summary
Research overview of TB-500 (Thymosin Beta-4): cell-migration mechanism, evidence classification, and safety considerations. The system-wide complement to BPC-157.
Reconstitution Cheat Sheet
Never second-guess your math again. BAC water ratios, syringe unit conversions, storage temps, and step-by-step reconstitution for every common peptide vial size.
Peptide Cycling Calendar
Blank cycling calendar template for tracking your peptide protocol schedule. Pre-filled protocols with compound-specific cycling schedules are generated inside DoseCraft's protocol engine.
Growth Hormone Peptide Comparison
Side-by-side breakdown of CJC-1295, Ipamorelin, Tesamorelin, Sermorelin, and MK-677. Compare mechanisms, half-lives, side effects, and optimal stacking combos.
The Mitochondrial Primer
Deep dive into mitochondrial function, ATP production, and how targeted peptides (SS-31, MOTS-c, Humanin) support cellular energy. The science behind the third root cause.
Vendor Red Flags: Sourcing Safety Guide
How to evaluate peptide vendors. Third-party testing, COA verification, purity thresholds, and the red flags that signal contaminated or underdosed product.
Hashimoto Reversal Quick-Start
Hashimoto is not a thyroid disease — it's an immune-system failure surfacing in the thyroid. The literature describes three biological failures (inflammation, insulin resistance, ATP shortage) converging to drive autoimmune attack. The upstream protocol — KPV + transdermal nicotine + BPC-157 + retatrutide + thymosin-α1 — addresses all three. Research describes 92% complete TPO antibody normalization at 24 weeks.
PCOS Insulin-Reset Quick-Start
PCOS is research-described as fundamentally an insulin-resistance condition — hormonal symptoms are downstream. Address insulin at the upstream driver and the ovarian androgen excess, cycle irregularity, and ovulation suppression normalize. The triple-agonist protocol (retatrutide + 40:1 inositol + MOTS-c + BPC-157) targets insulin resistance at the mitochondrial level + the gut-driven inflammation amplifying it.
Sleep Architecture Reset Quick-Start
Sleep architecture (deep + REM stages) is what restores you — not total time. The protocol restores the natural GH pulse during slow-wave sleep (CJC + Ipamorelin), repairs circadian rhythm at the genetic level (Epitalon 20-day cycles), and addresses the HPA-axis layer fragmenting sleep onset (Selank). Research describes 15–30% slow-wave increase within 4 weeks.
Fatigue Over 40 — The Three-Failure Reset
Age-related fatigue has measurable cellular drivers: the three biological failures (inflammation, insulin resistance, ATP shortage) compound after 40. The 4-peptide foundation (MOTS-c + Epitalon + BPC-157 + Thymosin-α1) addresses all three failures + the aging immune system in one integrated stack. Retatrutide adds the metabolic-efficiency layer when insulin-resistance overlay is present.
Anxiety Without Benzodiazepines — Selank Quick-Start
Benzodiazepines work — but at the cost of sedation, dependence, and cognitive blunting. Selank produces comparable anxiolytic effect without those tradeoffs (research-described as comparable to medazepam in generalized anxiety trials). Layered with Semax (BDNF-axis stress resilience) + magnesium glycinate (GABA-A cofactor) for the full protocol.
Migraine Reversal — Mitochondrial Reset
Migraine is research-described as an ATP-shortage manifestation — cortical spreading depolarization occurs when neuronal energy reserves are depleted by a trigger. The protocol raises the cellular-energy floor: MOTS-c (mitochondrial biogenesis), magnesium (NMDA + GABA + mitochondrial cofactor), riboflavin + CoQ10 (electron-transport cofactors), Selank (HPA-axis trigger amplification). Research describes 50–70% attack-frequency reduction at 16 weeks.
Wolverine Protocol — Joint, Tendon & Ligament Recovery
Connective tissue heals slowly because it's poorly vascularized — the repair signal can't reach the damage. The Wolverine Protocol solves the blood-supply problem at the injury site, then runs the three phases of repair in sequence: BPC-157 signals angiogenesis AT the injury site (paracrine — site matters), TB-500 organizes collagen along stress lines (not scar tissue), GHK-Cu finishes with 4,000-gene tissue remodeling. Research describes a structured 4–6 week window compressing what conservative care draws out for 4–6 months.
Gut Healing — IBS / Leaky Gut Reversal Quick-Start
The gut wall is an active immune organ — ~70% of immune tissue sits behind it. When tight junctions fail, undigested protein, bacterial LPS, and inflammatory fragments leak into circulation and drive IBS, fatigue, autoimmunity, skin reactivity, anxiety, and brain fog from one upstream substrate. The peptide protocol — oral BPC-157 + oral KPV + short-cycle SubQ LL-37 — addresses the three distinct failures: barrier disruption (tight-junction loss), NF-κB inflammatory storm, and biofilm-protected dysbiosis. Research describes Calprotectin normalization and symptom resolution in a meaningful majority at 12 weeks.
Cognitive Clarity — Brain Fog, Cognitive Decline & TBI Recovery
Brain fog is research-described as a neurobiological event — neuroinflammation, mitochondrial dysfunction in neurons, and impaired BDNF signaling — not willpower. The protocol addresses all three upstream drivers: Semax (intranasal, BDNF + cerebral blood flow within 2–5 days), Selank (GABA-A modulation without sedation), Methylene Blue (Complex IV bypass — pharmaceutical grade ONLY, 0.5–1 mg, hormetic curve). The TBI tier adds physician-administered Cerebrolysin + BPC-157 for structural injury. CRITICAL: Methylene Blue is a MAOI — life-threatening serotonin syndrome risk with any SSRI/SNRI/serotonergic medication. Use Semax + Selank alternative if you take any antidepressant.
Top 4 Forever — The Irreducible Longevity Stack
Nearly every chronic disease traces upstream to three biological failures: systemic inflammation, insulin resistance, and mitochondrial ATP shortage. Leading practitioners describe a four-compound stack — MOTS-c, Epitalon, BPC-157, Thymosin Alpha-1 — addressing all three root causes with no mechanism overlap. The 'irreducible minimum' for lifelong optimization. Mandatory staggered introduction (BPC-157 alone → +MOTS-c → +TA-1 → +Epitalon over 8 weeks) prevents the hs-CRP > 3.0 paradoxical-fatigue trap. Seasonal optimization syncs Epitalon cycles with solstice / equinox transitions.
Post-Viral Recovery — Immune Reconstitution Quick-Start
Post-viral syndromes are an immune-reset failure — not a willpower problem. Research describes three persistent failures: ongoing immune activation without an active threat, mitochondrial NAD+ depletion from the viral immune response, and T-cell exhaustion that leaves immunity simultaneously overactivated and underperforming. Thymosin Alpha-1 — FDA-approved as adjunctive therapy for melanoma and hepatitis B and authorized in 35+ countries for hepatitis, immunodeficiency, and vaccine-adjuvant use — addresses the T-cell training failure at its source. The 3-phase ramp (Acute Recovery → Rebuilding → Maintenance) is paired with BPC-157 as the anti-inflammatory floor and NMN for NAD+ restoration. This is the strongest regulatory-credibility anchor in the entire Dosecraft compound library.
Not medical advice — educational only. These guides are for informational and research purposes only. DoseCraft does not provide medical advice, diagnosis, or treatment. Always consult a licensed healthcare professional before starting any peptide protocol.