Enclomiphene
Androxal
A selective estrogen receptor modulator (SERM) that stimulates endogenous testosterone production without suppressing the HPT axis. Alternative to TRT for younger men wanting to preserve fertility and natural hormone production.
Half-life
10 hours
Typical Dose
12.5–25 mg/day
15/25Route
oral
Category
sexual_health
Evidence Overview
Strength of evidence across clinical, expert, and experimental lanes.
How Enclomiphene is dosed in practice
Usually taken by mouth. Typical range: 12.5–25 mg/day. Half-life: 10 hours. Each card gives the dose, frequency and duration from one evidence lane: Clinical (human trials), Expert (practitioner protocols) or Experimental (early or animal data). These ranges describe what has been studied or used; they are not a prescription.
Work out the units to draw with the reconstitution calculator, how long a vial lasts with the vial duration calculator, and how levels fall between doses with the half-life calculator.
Phase 3 trials (2016) of 12.5 or 25 mg daily for 16 weeks raised total testosterone from about 205 to 410–450 ng/dL and kept sperm concentration normal, while testosterone gel lowered it. Not FDA-approved.
- Kaminetsky et al., 2013 — Fertility and Sterility
- Androxal Phase III trial data — Repros Therapeutics
- Kim et al., 2020 — Andrologia
Increasingly prescribed as TRT alternative for men under 35 with secondary hypogonadism. Maintains fertility while boosting testosterone. Some practitioners use 12.5 mg EOD to start, titrating based on labs.
- Male fertility clinic protocols 2024
- Anti-aging practitioner consensus on SERMs
- Defy Medical enclomiphene protocols
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Upgrade to ProSafety & Contraindications
- Liver disease or elevated liver enzymes
- Venous thromboembolism history
- Hormone-sensitive cancers
Enclomiphene: common questions
What is Enclomiphene?
A selective estrogen receptor modulator (SERM) that stimulates endogenous testosterone production without suppressing the HPT axis. Alternative to TRT for younger men wanting to preserve fertility and natural hormone production.
How is Enclomiphene dosed?
Enclomiphene is usually taken by mouth. Typical range in DoseCraft's library: 12.5–25 mg/day. Clinical (human trials): 12.5–25 mg daily; Once daily; 16 weeks in phase 3 trials. Expert (practitioner protocols): 12.5 mg EOD to 25 mg daily; Daily or every other day; Ongoing with quarterly labs. These ranges describe what has been studied or used; they are not a prescription.
Is Enclomiphene FDA-approved?
Enclomiphene is not an FDA-approved finished drug. DoseCraft's library lists it as prepared by compounding pharmacies, which depends on current FDA rules for that substance.
What is the half-life of Enclomiphene?
DoseCraft's library lists a half-life of 10 hours. Half-life sets how often a compound is dosed and how long it takes to clear: about five half-lives.
Who should not use Enclomiphene?
Listed contraindications: Liver disease or elevated liver enzymes; Venous thromboembolism history; Hormone-sensitive cancers.
Information is for educational purposes only. Always consult a licensed healthcare provider before starting any peptide regimen.
Page updated . How we grade evidence: methodology.