Epifamin
Pineal gland bioregulator / Epiphysis peptide extract
A Russian pineal gland extract from bovine tissue, sold in Russia as a dietary supplement. It is promoted for sleep, circadian rhythm and healthy aging, but human evidence is limited to small Russian studies that measured blood markers. Distinct from Epithalon (a synthetic peptide); not FDA-approved.
Half-life
~3–4 hours (peptide fractions; pineal effects last 12–24 hours)
Typical Dose
10 mg 2–3x/day for 10–15 days
1.7999999999999998/3Route
oral
Category
sleep
Evidence Overview
Strength of evidence across clinical, expert, and experimental lanes.
How Epifamin is dosed in practice
Usually taken by mouth. Typical range: 10 mg 2–3x/day for 10–15 days. Half-life: ~3–4 hours (peptide fractions; pineal effects last 12–24 hours). Each card gives the dose, frequency and duration from one evidence lane: Clinical (human trials), Expert (practitioner protocols) or Experimental (early or animal data). These ranges describe what has been studied or used; they are not a prescription.
Work out the units to draw with the reconstitution calculator, how long a vial lasts with the vial duration calculator, and how levels fall between doses with the half-life calculator.
Sold in Russia as a dietary supplement, not a registered medicine. Evidence is limited to small Russian add-on studies (asthma, thyrotoxicosis, hepatitis) that mostly measured blood markers.
- Russian add-on study (2010)
- Russian study in asthma (2001)
Used by anti-aging practitioners for patients with disrupted circadian rhythms and declining melatonin production. Preferred over exogenous melatonin by some clinicians because it restores endogenous production rather than providing external hormone. Often combined with Epithalon in comprehensive anti-aging protocols.
- European anti-aging medicine practitioners
- Khavinson bioregulator therapy protocols
- Longevity clinic treatment plans
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Upgrade to ProSafety & Contraindications
- Autoimmune conditions (neuroendocrine modulation risk)
- Known allergy to bovine-derived products
- Concurrent melatonin supplementation (additive effects)
Epifamin: common questions
What is Epifamin?
A Russian pineal gland extract from bovine tissue, sold in Russia as a dietary supplement. It is promoted for sleep, circadian rhythm and healthy aging, but human evidence is limited to small Russian studies that measured blood markers. Distinct from Epithalon (a synthetic peptide); not FDA-approved.
How is Epifamin dosed?
Epifamin is usually taken by mouth. Typical range in DoseCraft's library: 10 mg 2–3x/day for 10–15 days. Clinical (human trials): 10 mg by mouth three times daily (2010 study); a 400 mg total course (2001 study); Three times daily before meals; 7 days in the 2010 study. Expert (practitioner protocols): 10 mg 2–3x/day; 2–3 times daily during treatment course; 10–15 day courses, 2–4 times per year. These ranges describe what has been studied or used; they are not a prescription.
Is Epifamin FDA-approved?
Epifamin is sold as a dietary supplement, which the FDA does not approve for safety or effectiveness before sale.
What is the half-life of Epifamin?
DoseCraft's library lists a half-life of ~3–4 hours (peptide fractions; pineal effects last 12–24 hours). Half-life sets how often a compound is dosed and how long it takes to clear: about five half-lives.
Who should not use Epifamin?
Listed contraindications: Autoimmune conditions (neuroendocrine modulation risk); Known allergy to bovine-derived products; Concurrent melatonin supplementation (additive effects).
Information is for educational purposes only. Always consult a licensed healthcare provider before starting any peptide regimen.
Page updated . How we grade evidence: methodology.