Mechano Growth Factor (MGF)
MGF / IGF-1Ec / Mechano Growth Factor
A splice variant of IGF-1 (specifically IGF-1Ec in humans) that is produced locally in muscle tissue in response to mechanical damage from exercise. Activates satellite cells (muscle stem cells), initiating muscle repair and hypertrophy. Extremely short half-life requires site-specific injection into the target muscle immediately post-workout.
Half-life
~5–7 minutes
Typical Dose
200 mcg per injection (site-specific)
Route
intramuscular
Category
growth_hormone
Evidence Overview
Strength of evidence across clinical, expert, and experimental lanes.
How Mechano Growth Factor (MGF) is dosed in practice
Usually taken by intramuscular injection. Typical range: 200 mcg per injection (site-specific). Half-life: ~5–7 minutes. Each card gives the dose, frequency and duration from one evidence lane: Clinical (human trials), Expert (practitioner protocols) or Experimental (early or animal data). These ranges describe what has been studied or used; they are not a prescription.
Work out the units to draw with the reconstitution calculator, how long a vial lasts with the vial duration calculator, and how levels fall between doses with the half-life calculator.
Used by advanced bodybuilders for localized muscle growth. Must be injected directly into the target muscle within minutes of training due to the ultra-short half-life. Users report enhanced soreness and accelerated recovery when injected bilaterally into lagging body parts. Rapidly being replaced by PEG-MGF in practice.
- Advanced bodybuilding peptide protocols
- Site-enhancement injection community discussions
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Upgrade to ProSafety & Contraindications
- Cancer history (IGF-1 pathway stimulation)
- Injection site infection risk (intramuscular, site-specific)
- Pregnancy or breastfeeding
Mechano Growth Factor (MGF): common questions
What is Mechano Growth Factor (MGF)?
A splice variant of IGF-1 (specifically IGF-1Ec in humans) that is produced locally in muscle tissue in response to mechanical damage from exercise. Activates satellite cells (muscle stem cells), initiating muscle repair and hypertrophy. Extremely short half-life requires site-specific injection into the target muscle immediately post-workout.
How is Mechano Growth Factor (MGF) dosed?
Mechano Growth Factor (MGF) is usually taken by intramuscular injection. Typical range in DoseCraft's library: 200 mcg per injection (site-specific). Experimental (early or animal data): 200 mcg per muscle group, post-workout; Training days only; 4–6 weeks. These ranges describe what has been studied or used; they are not a prescription.
Is Mechano Growth Factor (MGF) FDA-approved?
No. Mechano Growth Factor (MGF) is not approved by the FDA for any use in people.
What is the half-life of Mechano Growth Factor (MGF)?
DoseCraft's library lists a half-life of ~5–7 minutes. Half-life sets how often a compound is dosed and how long it takes to clear: about five half-lives.
Who should not use Mechano Growth Factor (MGF)?
Listed contraindications: Cancer history (IGF-1 pathway stimulation); Injection site infection risk (intramuscular, site-specific); Pregnancy or breastfeeding.
Information is for educational purposes only. Always consult a licensed healthcare provider before starting any peptide regimen.
Page updated . How we grade evidence: methodology.