Palmitoyl Tetrapeptide-7
Pal-GQPR / Rigin / Palmitoyl Tetrapeptide-3
A lipopeptide that suppresses interleukin-6 (IL-6) secretion and reduces chronic, low-grade skin inflammation known as 'inflammaging.' By modulating the inflammatory cascade in aging skin, it slows the degradation of collagen and elastin that drives photoaging. Often combined with Palmitoyl Oligopeptide in the Matrixyl 3000 complex for synergistic anti-aging effects.
Half-life
N/A (topical — local effect in skin)
Typical Dose
1–5% in topical formulation
Route
topical
Category
anti_aging
Evidence Overview
Strength of evidence across clinical, expert, and experimental lanes.
How Palmitoyl Tetrapeptide-7 is dosed in practice
Usually taken on the skin. Typical range: 1–5% in topical formulation. Half-life: N/A (topical — local effect in skin). Each card gives the dose, frequency and duration from one evidence lane: Clinical (human trials), Expert (practitioner protocols) or Experimental (early or animal data). These ranges describe what has been studied or used; they are not a prescription.
Work out the units to draw with the reconstitution calculator, how long a vial lasts with the vial duration calculator, and how levels fall between doses with the half-life calculator.
Valued by cosmetic chemists and dermatologists for addressing the inflammatory component of skin aging. Rarely used alone — typically formulated as part of the Matrixyl 3000 complex. A key active in premium anti-aging products. The inflammaging angle is increasingly recognized as critical to comprehensive skin aging management.
- Cosmetic dermatology clinical practice
- Anti-aging formulation development guidelines
- Professional skincare ingredient evaluations
Less well-known than Argireline or Matrixyl among consumers but gaining recognition in the skincare community. Users who incorporate Matrixyl 3000 products report better anti-aging results than Matrixyl alone. The anti-inflammatory angle resonates particularly with users who have sensitive or rosacea-prone skin.
- Skincare community product reviews — Matrixyl 3000
- Reddit r/SkincareAddiction — peptide serum threads
- Consumer cosmetic ingredient comparison discussions
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Upgrade to ProSafety & Contraindications
- Known hypersensitivity to peptide ingredients
- Active skin infections (anti-inflammatory effect may mask symptoms)
Palmitoyl Tetrapeptide-7: common questions
What is Palmitoyl Tetrapeptide-7?
A lipopeptide that suppresses interleukin-6 (IL-6) secretion and reduces chronic, low-grade skin inflammation known as 'inflammaging.' By modulating the inflammatory cascade in aging skin, it slows the degradation of collagen and elastin that drives photoaging. Often combined with Palmitoyl Oligopeptide in the Matrixyl 3000 complex for synergistic anti-aging effects.
How is Palmitoyl Tetrapeptide-7 dosed?
Palmitoyl Tetrapeptide-7 is usually taken on the skin. Typical range in DoseCraft's library: 1–5% in topical formulation. Expert (practitioner protocols): As part of Matrixyl 3000 complex, 2–5%; 2x daily; Ongoing. Experimental (early or animal data): In Matrixyl 3000 products, topical; 2x daily; Ongoing. These ranges describe what has been studied or used; they are not a prescription.
Is Palmitoyl Tetrapeptide-7 FDA-approved?
No. Palmitoyl Tetrapeptide-7 is not FDA-approved and is sold outside regulated drug channels.
What is the half-life of Palmitoyl Tetrapeptide-7?
DoseCraft's library lists a half-life of N/A (topical — local effect in skin). Half-life sets how often a compound is dosed and how long it takes to clear: about five half-lives.
Who should not use Palmitoyl Tetrapeptide-7?
Listed contraindications: Known hypersensitivity to peptide ingredients; Active skin infections (anti-inflammatory effect may mask symptoms).
Information is for educational purposes only. Always consult a licensed healthcare provider before starting any peptide regimen.
Page updated . How we grade evidence: methodology.