Pregnenolone
Preg
The 'master' precursor hormone from which all steroid hormones are synthesized. Supports neurosteroid production, cognitive function, and mood. Often depleted during TRT due to HPT axis suppression.
Half-life
1–2 hours
Typical Dose
50–100 mg/day
60/100Route
oral
Category
metabolic
Evidence Overview
Strength of evidence across clinical, expert, and experimental lanes.
How Pregnenolone is dosed in practice
Usually taken by mouth. Typical range: 50–100 mg/day. Half-life: 1–2 hours. Each card gives the dose, frequency and duration from one evidence lane: Clinical (human trials), Expert (practitioner protocols) or Experimental (early or animal data). These ranges describe what has been studied or used; they are not a prescription.
Work out the units to draw with the reconstitution calculator, how long a vial lasts with the vial duration calculator, and how levels fall between doses with the half-life calculator.
Human randomized trials are add-on studies in schizophrenia and bipolar depression with mixed results: some improvement in negative symptoms, functioning or depression, and no consistent effect on cognition. No trials in healthy adults for memory or stress.
- Add-on randomized trials in schizophrenia and bipolar depression
Increasingly added to TRT protocols to replace suppressed endogenous production. Practitioners report patients feel 'more complete' with pregnenolone added. Typical dose 50–100 mg morning with DHEA.
- TRT optimization practitioner protocols
- Functional medicine hormone restoration guidelines
- Neurosteroid replacement clinical research
Unlock Full Evidence Sources
Get complete clinical data, expert protocols, and experimental research for Pregnenolone and 90+ other compounds with Pro.
Upgrade to ProSafety & Contraindications
- Hormone-sensitive cancers
- Seizure disorders (neurosteroid activity)
- Pregnancy or breastfeeding
Pregnenolone: common questions
What is Pregnenolone?
The 'master' precursor hormone from which all steroid hormones are synthesized. Supports neurosteroid production, cognitive function, and mood. Often depleted during TRT due to HPT axis suppression.
How is Pregnenolone dosed?
Pregnenolone is usually taken by mouth. Typical range in DoseCraft's library: 50–100 mg/day. Clinical (human trials): 50–500 mg/day as add-on therapy in psychiatric patients; Daily; 8–12 weeks. Expert (practitioner protocols): 50–100 mg daily; Once daily (morning); Ongoing with TRT. These ranges describe what has been studied or used; they are not a prescription.
Is Pregnenolone FDA-approved?
Pregnenolone is sold as a dietary supplement, which the FDA does not approve for safety or effectiveness before sale.
What is the half-life of Pregnenolone?
DoseCraft's library lists a half-life of 1–2 hours. Half-life sets how often a compound is dosed and how long it takes to clear: about five half-lives.
Who should not use Pregnenolone?
Listed contraindications: Hormone-sensitive cancers; Seizure disorders (neurosteroid activity); Pregnancy or breastfeeding.
Information is for educational purposes only. Always consult a licensed healthcare provider before starting any peptide regimen.
Page updated . How we grade evidence: methodology.