Resveratrol
Trans-Resveratrol / 3,5,4'-Trihydroxystilbene
A polyphenolic stilbene found in red grapes, berries, and peanuts. Activates SIRT1 (a NAD+-dependent deacetylase), AMPK, and Nrf2 antioxidant pathways. Gained fame through a 2003 yeast study reporting longer lifespan, followed by worm and fly studies and a 2006 study in which it improved survival of mice on a high-calorie diet. Effects on human longevity remain debated, but anti-inflammatory, cardioprotective, and neuroprotective properties are well-documented.
Half-life
1–3 hours (but metabolites persist longer)
Typical Dose
250–1000 mg/day
600/1000Route
oral
Category
metabolic
Evidence Overview
Strength of evidence across clinical, expert, and experimental lanes.
How Resveratrol is dosed in practice
Usually taken by mouth. Typical range: 250–1000 mg/day. Half-life: 1–3 hours (but metabolites persist longer). Each card gives the dose, frequency and duration from one evidence lane: Clinical (human trials), Expert (practitioner protocols) or Experimental (early or animal data). These ranges describe what has been studied or used; they are not a prescription.
Work out the units to draw with the reconstitution calculator, how long a vial lasts with the vial duration calculator, and how levels fall between doses with the half-life calculator.
A metabolic study (2011) gave 150 mg/day for 30 days. A 2020 systematic review found only three small diabetes trials (10–1,000 mg/day for 4–5 weeks) and low-certainty evidence.
- Metabolic study (2011)
- Systematic review in diabetes (2020)
Longevity practitioners typically use 500–1000 mg daily with a fat-containing food for absorption, often alongside NMN. Many are cautious because the human data are weaker than the animal studies. Micronized or liposomal forms improve bioavailability; it degrades with light and heat.
- Longevity medicine polyphenol strategies
- Resveratrol bioavailability optimization research
A staple in the longevity supplement community despite ongoing debate about human efficacy. Users typically combine with NMN and report subjective improvements in energy and skin quality. Trans-resveratrol from Japanese knotweed (Polygonum cuspidatum) is the most common supplement source. Quality varies enormously between brands.
- Longevity supplement community protocols
- r/Supplements resveratrol discussion threads
Unlock Full Evidence Sources
Get complete clinical data, expert protocols, and experimental research for Resveratrol and 90+ other compounds with Pro.
Upgrade to ProSafety & Contraindications
- Anticoagulant therapy (resveratrol has mild antiplatelet activity)
- Estrogen-sensitive conditions (weak estrogenic activity)
- Surgery within 2 weeks (bleeding risk)
Resveratrol: common questions
What is Resveratrol?
A polyphenolic stilbene found in red grapes, berries, and peanuts. Activates SIRT1 (a NAD+-dependent deacetylase), AMPK, and Nrf2 antioxidant pathways. Gained fame through a 2003 yeast study reporting longer lifespan, followed by worm and fly studies and a 2006 study in which it improved survival of mice on a high-calorie diet. Effects on human longevity remain debated, but anti-inflammatory, cardioprotective, and neuroprotective properties are well-documented.
How is Resveratrol dosed?
Resveratrol is usually taken by mouth. Typical range in DoseCraft's library: 250–1000 mg/day. Clinical (human trials): 150–1,000 mg daily in trials (10 mg in one); Daily; About 4–5 weeks in the reviewed trials. Expert (practitioner protocols): 500–1000 mg daily with fat; Once daily with breakfast; Ongoing. Experimental (early or animal data): 500–1000 mg daily; Once daily; Ongoing. These ranges describe what has been studied or used; they are not a prescription.
Is Resveratrol FDA-approved?
Resveratrol is sold as a dietary supplement, which the FDA does not approve for safety or effectiveness before sale.
What is the half-life of Resveratrol?
DoseCraft's library lists a half-life of 1–3 hours (but metabolites persist longer). Half-life sets how often a compound is dosed and how long it takes to clear: about five half-lives.
Who should not use Resveratrol?
Listed contraindications: Anticoagulant therapy (resveratrol has mild antiplatelet activity); Estrogen-sensitive conditions (weak estrogenic activity); Surgery within 2 weeks (bleeding risk).
Information is for educational purposes only. Always consult a licensed healthcare provider before starting any peptide regimen.
Page updated . How we grade evidence: methodology.