Selank
TP-7 — synthetic heptapeptide (anxiolytic nootropic)
Selank is a synthetic seven-amino-acid peptide based on tuftsin, a natural immune peptide, developed in Russia as an anti-anxiety medicine. It is not approved in the US or EU. Evidence comes from small Russian clinical studies in anxiety and from animal studies; there are no Western trials.
Quick reference
How Selank is dosed in practice
Selank is usually taken as a nasal spray: 250–400 mcg per dose, once or twice a day. With the 2 mg/mL solution below, that's roughly 1–2 sprays per dose.
Courses typically last 10–14 days, followed by a break before another course. Many start once a day at the low end and add a second dose only if needed.
Where the numbers come from: Russian clinical use and practitioner convention. There are no Western dosing trials, and this guide doesn't list more than 400 mcg per dose or more than two doses a day.
Work out the units to draw with the reconstitution calculator and how long a vial lasts with the vial duration calculator.
How Selank works
Selank is derived from tuftsin, a natural immunomodulatory peptide. The Russian designers added a 4-amino-acid tail to extend half-life and enhance CNS penetration. The final 7-amino-acid sequence (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is what defines Selank's distinctive pharmacology.
In Russian and animal studies, Selank's effects have been linked to GABA-system modulation, changes in serotonin activity, and BDNF expression. Those studies reported reduced anxiety without sedation.
Intranasal use is standard because that is how Selank is registered in Russia and how it was studied.
In the DoseCraft framework, Selank is filed under Inflammation (stress reduction) and, indirectly, ATP Shortage — a framework placement, not a tested outcome.
Reconstitution math
- Remove the flip-off cap from the 5 mg vial.
- Draw 2.5 mL of bacteriostatic water into a sterile syringe.
- Inject slowly down the vial wall.
- Swirl gently. Transfer to a nasal spray bottle for intranasal use.
- Refrigerate the nasal bottle. Stable approximately 30 days.
Dose math
5 mg vial + 2.5 mL bac water → 2,000 mcg/mL (2 mg/mL).
Nasal sprayers typically deliver 0.1 mL per spray:
- • 1 spray ≈ 200 mcg (depends on sprayer)
- • 2 sprays (one per nostril) ≈ 400 mcg — the most per dose
- • Typical dose: 1–2 sprays, once or twice a day
Safety + side-effect profile
Russian studies reported Selank as well tolerated, without sedation or dependence. Western safety data don't exist.
Not established: long-term safety. Avoid with: pregnancy, breastfeeding, psychotic disorders (no data).
Interaction notes: often paired with Semax. It may add to the effects of benzodiazepines and other anxiety medicines — don't combine them, or stop a prescribed medicine, without your prescriber.
- • Mild nasal irritation (uncommon)
- • Occasional bitter or metallic taste at the back of the throat
- • Mild headache in the first days (rare)
- • No sedation reported at usual doses
Frequently asked
What is Selank?
Selank is a synthetic seven-amino-acid peptide based on tuftsin, developed in Russia as an anti-anxiety medicine. It is not approved in the US or EU. Small Russian studies reported reduced anxiety without sedation.
What is the typical Selank dose?
250–400 mcg per dose as a nasal spray, once or twice a day, for 10–14 day courses with breaks in between. That's about 1–2 sprays per dose at 2 mg/mL. These amounts come from Russian clinical use and practitioner convention; this guide doesn't list more than 400 mcg per dose or two doses a day.
Is Selank addictive?
Russian studies did not report dependence or withdrawal. But it hasn't been studied for long-term use or in Western trials, so the dependence risk isn't fully known.
Selank vs Semax — when to use which?
Selank is used mainly for anxiety and calm focus; Semax mainly for alertness and cognition. Practitioners often pair them — Selank for calm, Semax for demanding cognitive work. Neither has Western trials.
Why intranasal instead of subcutaneous?
Selank is registered and was studied as a nasal preparation, so that's where the dosing experience comes from. Injected use is less studied.
Will Selank make me drowsy?
Russian studies reported anti-anxiety effects without sedation, and most users describe calm rather than drowsiness. Responses vary, so see how you react before driving.
Should I cycle Selank?
Courses of 10–14 days followed by a break are the common pattern, matching Russian clinical use. Longer continuous use hasn't been studied.
Are there safety concerns?
Reported effects are mild: occasional nasal irritation, a bitter or metallic taste, and rare headache in the first days. Long-term safety hasn't been studied, and there are no Western safety data.
Related compounds
Often researched, stacked, or compared with Selank.
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