Testosterone Cypionate
Test Cyp / Depo-Testosterone
Gold standard testosterone ester for TRT in the United States. Delivers stable serum testosterone levels with weekly or biweekly injections. FDA-approved for male hypogonadism with decades of clinical use.
Half-life
8–12 days
Typical Dose
100–200 mg/week
120/200Route
intramuscular
Category
sexual_health
Evidence Overview
Strength of evidence across clinical, expert, and experimental lanes.
How Testosterone Cypionate is dosed in practice
Usually taken by intramuscular injection. Typical range: 100–200 mg/week. Half-life: 8–12 days. Each card gives the dose, frequency and duration from one evidence lane: Clinical (human trials), Expert (practitioner protocols) or Experimental (early or animal data). These ranges describe what has been studied or used; they are not a prescription.
Work out the units to draw with the reconstitution calculator, how long a vial lasts with the vial duration calculator, and how levels fall between doses with the half-life calculator.
Label dosing for men with low testosterone is 50–400 mg IM every 2–4 weeks. Weekly or split twice-weekly dosing is common in practice but is not the label regimen.
- Drug label (Depo-Testosterone)
Modern TRT practitioners recommend split dosing (2x/week) for stable levels and fewer side effects. Pair with AI only when estradiol-related symptoms arise. Subcutaneous injection gaining popularity as alternative to IM.
- Leading TRT practitioners — modern protocols
- TRT clinic optimization protocols
- Defy Medical clinical guidelines
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Upgrade to ProSafety & Contraindications
- Prostate or breast cancer
- Polycythemia (hematocrit > 54%)
- Severe sleep apnea (untreated)
- Pregnancy (Category X)
Testosterone Cypionate: common questions
What is Testosterone Cypionate?
Gold standard testosterone ester for TRT in the United States. Delivers stable serum testosterone levels with weekly or biweekly injections. FDA-approved for male hypogonadism with decades of clinical use.
How is Testosterone Cypionate dosed?
Testosterone Cypionate is usually taken by intramuscular injection. Typical range in DoseCraft's library: 100–200 mg/week. Clinical (human trials): 50–400 mg IM (label); Every 2–4 weeks; Ongoing replacement. Expert (practitioner protocols): 100–200 mg/week, weekly or split twice weekly; 2x per week (e.g., Monday/Thursday); Ongoing — lifetime protocol. These ranges describe what has been studied or used; they are not a prescription.
Is Testosterone Cypionate FDA-approved?
Yes. Testosterone Cypionate is an FDA-approved prescription medicine; uses outside its approved indication are off-label.
What is the half-life of Testosterone Cypionate?
DoseCraft's library lists a half-life of 8–12 days. Half-life sets how often a compound is dosed and how long it takes to clear: about five half-lives.
Who should not use Testosterone Cypionate?
Listed contraindications: Prostate or breast cancer; Polycythemia (hematocrit > 54%); Severe sleep apnea (untreated); Pregnancy (Category X).
Free Guides for Testosterone Cypionate
Information is for educational purposes only. Always consult a licensed healthcare provider before starting any peptide regimen.
Page updated . How we grade evidence: methodology.