Triptorelin
Trelstar / Decapeptyl / GnRH Agonist
A potent GnRH agonist approved for advanced prostate cancer and central precocious puberty. In the biohacking/bodybuilding community, a single 100 mcg dose is used as a 'PCT nuclear option' — the massive initial LH/FSH surge (the flare effect) before receptor downregulation can restart the HPTA after prolonged anabolic steroid use. Extremely powerful and not to be used casually.
Half-life
~3 hours (but depot formulations last weeks)
Typical Dose
100 mcg single dose (PCT) or depot formulations
Route
intramuscular
Category
sexual_health
Evidence Overview
Strength of evidence across clinical, expert, and experimental lanes.
How Triptorelin is dosed in practice
Usually taken by intramuscular injection. Typical range: 100 mcg single dose (PCT) or depot formulations. Half-life: ~3 hours (but depot formulations last weeks). Each card gives the dose, frequency and duration from one evidence lane: Clinical (human trials), Expert (practitioner protocols) or Experimental (early or animal data). These ranges describe what has been studied or used; they are not a prescription.
Work out the units to draw with the reconstitution calculator, how long a vial lasts with the vial duration calculator, and how levels fall between doses with the half-life calculator.
Approved (as Trelstar) for advanced prostate cancer as an IM depot. A single low-dose injection is used in diagnostic GnRH-agonist stimulation tests, but no published human trial has tested a 100 mcg dose to restart testosterone after steroid use.
- Drug label (Trelstar)
Used as a 'last resort' PCT option after long steroid cycles when standard protocols (Nolvadex/Clomid) fail. A single 100 mcg SubQ/IM injection produces a massive LH/FSH surge. Do NOT repeat the dose — subsequent doses will cause chemical castration via receptor downregulation. Monitor testosterone recovery 4–6 weeks post-injection.
- Advanced PCT protocols
- Endocrinologist-supervised HPTA restart protocols
The 'Triptorelin PCT' is legendary in steroid communities. A single 100 mcg dose reportedly restarts testosterone production after prolonged shutdown. Success stories are dramatic but so are horror stories from repeated dosing. Consensus: use ONLY as a last resort, never more than once, and preferably under medical supervision.
- Steroid community PCT experience threads
- Bodybuilding forum Triptorelin success/failure reports
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Upgrade to ProSafety & Contraindications
- Hormone-sensitive cancers (initial flare can worsen)
- Osteoporosis risk with chronic use (hypogonadism induction)
- Pregnancy (absolutely contraindicated)
- Not for repeated use in PCT — single dose only
Triptorelin: common questions
What is Triptorelin?
A potent GnRH agonist approved for advanced prostate cancer and central precocious puberty. In the biohacking/bodybuilding community, a single 100 mcg dose is used as a 'PCT nuclear option' — the massive initial LH/FSH surge (the flare effect) before receptor downregulation can restart the HPTA after prolonged anabolic steroid use. Extremely powerful and not to be used casually.
How is Triptorelin dosed?
Triptorelin is usually taken by intramuscular injection. Typical range in DoseCraft's library: 100 mcg single dose (PCT) or depot formulations. Clinical (human trials): 3.75 mg every 4 weeks, 11.25 mg every 12 weeks or 22.5 mg every 24 weeks (depot); One depot injection per interval; Ongoing (prostate cancer). Expert (practitioner protocols): 100 mcg single dose; Once only (not to be repeated); Single injection, monitor recovery for 6–8 weeks. Experimental (early or animal data): 100 mcg single injection; Once — never repeat; Monitor recovery for 8–12 weeks. These ranges describe what has been studied or used; they are not a prescription.
Is Triptorelin FDA-approved?
Yes. Triptorelin is an FDA-approved prescription medicine; uses outside its approved indication are off-label.
What is the half-life of Triptorelin?
DoseCraft's library lists a half-life of ~3 hours (but depot formulations last weeks). Half-life sets how often a compound is dosed and how long it takes to clear: about five half-lives.
Who should not use Triptorelin?
Listed contraindications: Hormone-sensitive cancers (initial flare can worsen); Osteoporosis risk with chronic use (hypogonadism induction); Pregnancy (absolutely contraindicated); Not for repeated use in PCT — single dose only.
Information is for educational purposes only. Always consult a licensed healthcare provider before starting any peptide regimen.
Page updated . How we grade evidence: methodology.